To compare the value of inferior vena cava (IVC) variation, thoracic fluid content (TFC), and central venous pressure (CVP) in transurethral resection of the prostate (TURP) for systemic volumetric load. Eighty male patients who had undergone TURP at our hospital from July to August 2021 were enrolled. Before and after anesthesia induction, IVC variation and TFC were recorded every 15 min and then 15 min after surgery. The ability of IVC variation, TFC, and CVP to predict fluid responsiveness was assessed using receiver operator characteristic (ROC) curves. The Pearson correlation test was used to analyze the correlations among intraoperative IVC variation, TFC, CVP and the stroke volume index (SVI). ROC curve evaluation: the area under the ROC curve (AUC) of IVC variation was 0.82 (p < 0.01), while that of CVP and TFC was 0.61 (p = 0.16) and 0.45 (p = 0.28), respectively. Since the operation began, ∆IVC variation showed a significant negative correlation with ∆SVI at different time points. ∆CVP and ∆TFC showed a poor correlation with ∆SVI. IVC variation was superior to TFC and CVP to predict fluid responsiveness and assess the volume status and volume responsiveness of patients undergoing TURP.