醇溶蛋白
生物利用度
纳米颗粒
化学
化学工程
姜黄素
核化学
分散性
粒径
色谱法
有机化学
食品科学
生物化学
生物
工程类
物理化学
生物信息学
面筋
作者
Siyan Guo,Yanyan Zhao,Shuizhong Luo,Dezhi Mu,Xingjiang Li,Xiyang Zhong,Shaotong Jiang,Zhi Zheng
摘要
Abstract BACKGROUND Gliadin nanoparticles are used as a delivery system for active substances because of their amphiphilicity and bioavailability. However, they are susceptible to destabilization by external agents. In this study, gliadin nanoparticles stabilized by soluble soybean polysaccharide (SSPS) were prepared by antisolvent precipitation. Formed stable complex nanoparticles were applied to protect and deliver curcumin (Cur). RESULTS Gliadin/SSPS nanoparticles with the smallest particle size (196.66 nm, polydispersity index < 0.2) were fabricated when the mass ratio of gliadin to SSPS was 1:1 at pH 5.0. SSPS‐stabilized gliadin nanoparticles had excellent stability at pH 3.0–8.0, 0.02–0.1 mol L −1 NaCl and at 90 °C heat. Gliadin/SSPS nanoparticles were used to encapsulate the Cur. The encapsulation efficiency of the Cur‐loaded gliadin/SSPS nanoparticles was 84.59%. Fourier transform infrared spectroscopy and fluorescence spectrophotometry showed that the main forces were hydrogen bonds, electrostatic interactions and hydrophobic interactions between gliadin and SSPS. The X‐ray diffraction patterns exhibited that the crystalline form of Cur converted to an amorphous substance. The retention rates of Cur‐loaded gliadin/SSPS nanoparticles reached 79.03%, 73.43% and 87.92% after ultraviolet irradiation for 4 h, heating at 90 °C and storage at 25 °C for 15 days, respectively. Additionally, simulated digestion demonstrated that the bioavailability of gliadin/SSPS‐Cur nanoparticles was four times higher than that of free Cur. CONCLUSION This study showed that SSPS improved the stability of gliadin nanoparticles. Gliadin/SSPS nanoparticles have the function of loading and delivering Cur. © 2022 Society of Chemical Industry
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