Blue light induces skin apoptosis and degeneration through activation of the endoplasmic reticulum stress-autophagy apoptosis axis: Protective role of hydrogen sulfide

自噬 未折叠蛋白反应 内质网 细胞生物学 细胞凋亡 程序性细胞死亡 氧化应激 活性氧 化学 生物 生物化学
作者
Sen Zhu,Xuan Li,Fen Wu,Xinhui Cao,Kexin Gou,Chunming Wang,Changjun Lin
出处
期刊:Journal of Photochemistry and Photobiology B-biology [Elsevier]
卷期号:229: 112426-112426 被引量:9
标识
DOI:10.1016/j.jphotobiol.2022.112426
摘要

Research on the phototoxicity of blue light (BL) to the skin is increasing. Although blue light can induce oxidative stress, inflammation, and inhibition of proliferation in skin cells, the mechanism by which blue light damages the skin is not yet clear. Endoplasmic reticulum (ER) stress and autophagy are two mechanisms by which cells resist external interference factors and maintain cell homeostasis and normal function, and both can affect cell apoptosis. Interestingly, we have found that blue light (435 nm ~ 445 nm, 8000 lx, 6-24 h)-induced oxidative stress triggers the ER stress-CHOP (C/EBP homologous protein) signal and affects the protein levels of B-cell lymphoma-2 (Bcl-2) and Bcl2-associated X (Bax), thereby promoting apoptosis. In addition, blue light activates autophagy in skin cells, which intensifies cell death. When ER stress is inhibited, autophagy is subsequently inhibited, suggesting that blue light-induced autophagy is influenced by ER stress. These evidences suggest that blue light induces activation of reactive oxygen species (ROS)-ER stress-autophagy-apoptosis axis signaling, which further induces skin injury and apoptosis. This is the first report on the relationships among oxidative stress, ER stress, autophagy, and apoptosis in blue light-induced skin injury. Furthermore, we have studied the effect of hydrogen sulfide (H2S) on blue light-induced skin damage, and found that exogenous H2S can protect skin from blue light-induced damage by regulating the ROS-ER stress-autophagy-apoptosis axis. Our data shows that when we are exposed to blue light, such as sunbathing and jaundice treatment, H2S may be developed as a protective agent.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
@@完成签到,获得积分20
刚刚
1秒前
zqh应助彪壮的绮烟采纳,获得10
1秒前
Leo完成签到,获得积分10
1秒前
2秒前
2秒前
3秒前
@@发布了新的文献求助10
3秒前
3秒前
4秒前
狂野世立发布了新的文献求助10
4秒前
hanzhangjian发布了新的文献求助10
5秒前
小宋发布了新的文献求助10
6秒前
6秒前
橘子发布了新的文献求助10
7秒前
司si完成签到,获得积分10
7秒前
7秒前
李麟发布了新的文献求助10
10秒前
金刚经应助避橙采纳,获得10
10秒前
顺利山柏发布了新的文献求助10
11秒前
宇文远锋应助Mercury采纳,获得20
11秒前
独月映晨星完成签到,获得积分10
12秒前
12秒前
香蕉耳机发布了新的文献求助10
13秒前
wangyue发布了新的文献求助10
14秒前
LI完成签到 ,获得积分10
14秒前
16秒前
不配.应助谨慎山彤采纳,获得10
16秒前
17秒前
18秒前
orange完成签到,获得积分10
20秒前
hsialy发布了新的文献求助10
20秒前
coldsky完成签到,获得积分10
22秒前
23秒前
Anonymous发布了新的文献求助10
23秒前
上官若男应助打打采纳,获得10
23秒前
Hbobo发布了新的文献求助10
24秒前
在水一方应助吉吉采纳,获得10
26秒前
26秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
India's foreign trade policy and its performance in the world economy 450
Structural Inorganic Chemistry 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196094
求助须知:如何正确求助?哪些是违规求助? 2844876
关于积分的说明 8051936
捐赠科研通 2509483
什么是DOI,文献DOI怎么找? 1341737
科研通“疑难数据库(出版商)”最低求助积分说明 639244
邀请新用户注册赠送积分活动 608445