Blue light induces skin apoptosis and degeneration through activation of the endoplasmic reticulum stress-autophagy apoptosis axis: Protective role of hydrogen sulfide

自噬 未折叠蛋白反应 内质网 细胞生物学 细胞凋亡 程序性细胞死亡 氧化应激 活性氧 化学 生物 生物化学
作者
Sen Zhu,Xuan Li,Fen Wu,Xinhui Cao,Kexin Gou,Chunming Wang,Changjun Lin
出处
期刊:Journal of Photochemistry and Photobiology B-biology [Elsevier]
卷期号:229: 112426-112426 被引量:9
标识
DOI:10.1016/j.jphotobiol.2022.112426
摘要

Research on the phototoxicity of blue light (BL) to the skin is increasing. Although blue light can induce oxidative stress, inflammation, and inhibition of proliferation in skin cells, the mechanism by which blue light damages the skin is not yet clear. Endoplasmic reticulum (ER) stress and autophagy are two mechanisms by which cells resist external interference factors and maintain cell homeostasis and normal function, and both can affect cell apoptosis. Interestingly, we have found that blue light (435 nm ~ 445 nm, 8000 lx, 6-24 h)-induced oxidative stress triggers the ER stress-CHOP (C/EBP homologous protein) signal and affects the protein levels of B-cell lymphoma-2 (Bcl-2) and Bcl2-associated X (Bax), thereby promoting apoptosis. In addition, blue light activates autophagy in skin cells, which intensifies cell death. When ER stress is inhibited, autophagy is subsequently inhibited, suggesting that blue light-induced autophagy is influenced by ER stress. These evidences suggest that blue light induces activation of reactive oxygen species (ROS)-ER stress-autophagy-apoptosis axis signaling, which further induces skin injury and apoptosis. This is the first report on the relationships among oxidative stress, ER stress, autophagy, and apoptosis in blue light-induced skin injury. Furthermore, we have studied the effect of hydrogen sulfide (H2S) on blue light-induced skin damage, and found that exogenous H2S can protect skin from blue light-induced damage by regulating the ROS-ER stress-autophagy-apoptosis axis. Our data shows that when we are exposed to blue light, such as sunbathing and jaundice treatment, H2S may be developed as a protective agent.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
asdasdas完成签到,获得积分10
刚刚
我就是我完成签到,获得积分10
1秒前
2秒前
常山赵紫龍完成签到,获得积分10
2秒前
刻苦耐劳发布了新的文献求助10
2秒前
巴卡巴卡发布了新的文献求助10
2秒前
奇拉维特完成签到 ,获得积分10
3秒前
asdasdas发布了新的文献求助10
3秒前
靖靖吖完成签到,获得积分10
4秒前
长风完成签到 ,获得积分10
4秒前
彭于晏应助上好佳采纳,获得10
5秒前
6秒前
cwwqt完成签到,获得积分10
7秒前
7秒前
7秒前
lemon完成签到 ,获得积分10
8秒前
田様应助西贝尔采纳,获得10
9秒前
NexusExplorer应助YUMI采纳,获得10
9秒前
希望天下0贩的0应助hua采纳,获得10
9秒前
souther完成签到,获得积分0
10秒前
shania发布了新的文献求助10
10秒前
LZY发布了新的文献求助10
11秒前
不配.应助ll采纳,获得10
11秒前
15秒前
研友_VZG7GZ应助沈嘀嘀采纳,获得10
15秒前
大意的友琴完成签到,获得积分10
16秒前
杨攀玉发布了新的文献求助10
17秒前
18秒前
雾蒽完成签到,获得积分10
18秒前
善学以致用应助Chrischelsea采纳,获得10
18秒前
19秒前
香蕉觅云应助科研通管家采纳,获得10
19秒前
雪满头应助科研通管家采纳,获得10
19秒前
华仔应助科研通管家采纳,获得10
19秒前
桐桐应助科研通管家采纳,获得10
19秒前
吸金兽完成签到,获得积分10
19秒前
爆米花应助科研通管家采纳,获得10
19秒前
乐观银耳汤完成签到,获得积分10
19秒前
领导范儿应助辛勤的灵薇采纳,获得10
20秒前
科研小若狗完成签到,获得积分10
21秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3198017
求助须知:如何正确求助?哪些是违规求助? 2846971
关于积分的说明 8061481
捐赠科研通 2511842
什么是DOI,文献DOI怎么找? 1343748
科研通“疑难数据库(出版商)”最低求助积分说明 639617
邀请新用户注册赠送积分活动 609261