Blue light induces skin apoptosis and degeneration through activation of the endoplasmic reticulum stress-autophagy apoptosis axis: Protective role of hydrogen sulfide

自噬 未折叠蛋白反应 内质网 细胞生物学 细胞凋亡 程序性细胞死亡 氧化应激 活性氧 化学 生物 生物化学
作者
Sen Zhu,Xuan Li,Fen Wu,Xinhui Cao,Kexin Gou,Chunming Wang,Changjun Lin
出处
期刊:Journal of Photochemistry and Photobiology B-biology [Elsevier]
卷期号:229: 112426-112426 被引量:9
标识
DOI:10.1016/j.jphotobiol.2022.112426
摘要

Research on the phototoxicity of blue light (BL) to the skin is increasing. Although blue light can induce oxidative stress, inflammation, and inhibition of proliferation in skin cells, the mechanism by which blue light damages the skin is not yet clear. Endoplasmic reticulum (ER) stress and autophagy are two mechanisms by which cells resist external interference factors and maintain cell homeostasis and normal function, and both can affect cell apoptosis. Interestingly, we have found that blue light (435 nm ~ 445 nm, 8000 lx, 6-24 h)-induced oxidative stress triggers the ER stress-CHOP (C/EBP homologous protein) signal and affects the protein levels of B-cell lymphoma-2 (Bcl-2) and Bcl2-associated X (Bax), thereby promoting apoptosis. In addition, blue light activates autophagy in skin cells, which intensifies cell death. When ER stress is inhibited, autophagy is subsequently inhibited, suggesting that blue light-induced autophagy is influenced by ER stress. These evidences suggest that blue light induces activation of reactive oxygen species (ROS)-ER stress-autophagy-apoptosis axis signaling, which further induces skin injury and apoptosis. This is the first report on the relationships among oxidative stress, ER stress, autophagy, and apoptosis in blue light-induced skin injury. Furthermore, we have studied the effect of hydrogen sulfide (H2S) on blue light-induced skin damage, and found that exogenous H2S can protect skin from blue light-induced damage by regulating the ROS-ER stress-autophagy-apoptosis axis. Our data shows that when we are exposed to blue light, such as sunbathing and jaundice treatment, H2S may be developed as a protective agent.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
Chocolate发布了新的文献求助10
2秒前
2秒前
3秒前
学生小王完成签到,获得积分10
7秒前
飘逸晓山发布了新的文献求助10
7秒前
7秒前
北海西贝完成签到,获得积分10
8秒前
林飞双完成签到,获得积分20
9秒前
HP关闭了HP文献求助
10秒前
科研通AI2S应助坚强的安柏采纳,获得10
10秒前
11秒前
Chocolate完成签到,获得积分10
12秒前
12秒前
爱科研的小菠萝完成签到,获得积分10
15秒前
8R60d8应助Luoxin采纳,获得10
15秒前
123发布了新的文献求助10
16秒前
16秒前
xixiz1024发布了新的文献求助10
16秒前
瑶啊瑶发布了新的文献求助10
16秒前
领导范儿应助hk1900采纳,获得10
17秒前
多多洛发布了新的文献求助10
18秒前
xxx完成签到,获得积分10
20秒前
21秒前
21秒前
梦_筱彩完成签到 ,获得积分10
22秒前
23秒前
星程完成签到,获得积分10
23秒前
FashionBoy应助的如采纳,获得10
24秒前
25秒前
xixiz1024完成签到,获得积分10
25秒前
25秒前
HP关闭了HP文献求助
26秒前
星程发布了新的文献求助30
27秒前
27秒前
lily发布了新的文献求助10
27秒前
无耻之徒eleven完成签到,获得积分10
27秒前
hk1900发布了新的文献求助10
28秒前
28秒前
香妃发布了新的文献求助10
29秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189479
求助须知:如何正确求助?哪些是违规求助? 2838806
关于积分的说明 8021756
捐赠科研通 2501710
什么是DOI,文献DOI怎么找? 1335931
科研通“疑难数据库(出版商)”最低求助积分说明 637750
邀请新用户注册赠送积分活动 605810