荧光
体内
化学
纳米技术
量子产额
斯托克斯位移
聚集诱导发射
组合化学
临床前影像学
猝灭(荧光)
生物物理学
光化学
材料科学
物理
生物技术
生物
量子力学
作者
Tian‐Bing Ren,Zhiyao Wang,Zhen Xiang,Lu Peng,Huanhua Lai,Lin Yuan,Xiaobing Zhang,Weihong Tan
标识
DOI:10.1002/ange.202009986
摘要
Abstract Organic dye based NIR‐II fluorescent probes, owing to their high signal‐to‐background ratio and deeper penetration, are highly useful for deep‐tissue high‐contrast imaging in vivo. However, it is still a challenge to design activatable NIR‐II fluorescent probes. Here, a novel class of polymethine dyes (NIRII‐RTs), with bright (quantum yield up to 2.03 %), stable, and anti‐solvent quenching NIR‐II emission, together with large Stokes shifts, was designed. Significantly, the novel NIR‐II dyes NIRII‐RT3 and NIRII‐RT4, equipped with a carboxylic acid group, can serve as effective NIR‐II platforms for the design of activatable bioimaging probes with high contrast. As a proof of concept, a series of target‐activatable NIRII‐RT probes (NIRII‐RT‐pH, NIRII‐RT‐ATP and NIRII‐RT‐Hg) for pH, adenosine triphosphate (ATP), and metal‐ion detection, were synthesized. By applying the NIRII‐RT probe, the real‐time monitoring of drug‐induced hepatotoxicity was realized.
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