The Relationship between Dietary Copper intake and Telomere Length in Hypertension

医学 全国健康与营养检查调查 体质指数 置信区间 端粒 内科学 内分泌学 生理学 环境卫生 生物 遗传学 人口 DNA
作者
Huping Gong,Qian Yu,Mingjie Yuan,Yizhou Jiang,J. Wang,Pan Huang,Jianghua Zhou
出处
期刊:Journal of Nutrition Health & Aging [Springer Science+Business Media]
卷期号:26 (5): 510-514 被引量:15
标识
DOI:10.1007/s12603-022-1787-7
摘要

More indications proved that diet might be involved in the telomere length, a marker of biological aging and chronic diseases. Copper is widely viewed as one of the essential elements in the diet. Therefore, this study aimed to evaluate the relationship between telomere length and dietary copper intake in hypertension and provide a basis for guiding dietary copper intake in patients with hypertension. The data was collected from the National Health and Nutrition Examination Survey (NHANES) in 1999–2000 and 2001–2002. The relevance between telomere length and dietary copper intake in hypertension is assessed using a multivariable linear regression model. We gathered 1,867 participants with hypertension with assessed telomere length and dietary copper intake. We found that one unit increasing log-transformed dietary copper intake in hypertension was significantly associated with longer telomere length base pair (bp) (β = 112.20, 95% confidence interval [CI]: 5.48, 218.92), after controlling for covariates, including age, sex, ethnicity, body mass index (BMI), physical activity, and taking medication for hypertension. For the age group, we found that one unit increasing log-transformed dietary copper in hypertension was associated with longer telomere length (β = 237.95, 95% CI: 114.39, 361.51) in the age group >45 years. The grouping was based on whether the participants take medication for hypertension. We found that one unit increasing log-transformed dietary copper in hypertension was associated with longer telomere length (β = 116.47, 95% CI: 0.72, 232.21) in the group that takes medication for hypertension. This study demonstrates that dietary copper intake was associated with longer telomere length in patients with hypertension, which provides evidence for guiding dietary copper intake in patients with hypertension. However, further studies are needed to evaluate the effect of copper supplementation on telomere length in patients with hypertension in well-designed random control studies and prospective studies.
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