炎症
多酚
消炎药
细胞因子
巨噬细胞
NF-κB
分泌物
促炎细胞因子
肿瘤坏死因子α
抗氧化剂
药理学
化学
生物
免疫学
生物化学
体外
作者
Katarzyna Chojnacka,Urszula Lewandowska
标识
DOI:10.1080/87559129.2022.2071936
摘要
Macrophages play important roles in acute and chronic inflammation. Upon their activation, they secrete a variety of mediators, including cytokines, which are involved in the inflammatory response. Polyphenols are a wide group of compounds with many health-promoting properties. They are characterized by antioxidant, anti-cancer and anti-inflammatory activity. Numerous studies conducted on single phenols shed light on plant extracts rich in these compounds. The aim of this descriptive review is to demonstrate the anti-inflammatory role of phenol-rich natural extracts by modulating the NF-κB signaling pathway in macrophage cells. Additionally, this article focuses on the influence of phenolic extracts on the inhibition of pro-inflammatory cytokines, such as IL-1β, IL-6, TNF-α. The cited studies prove that plant extracts possess anti-inflammatory activity, and due to the wide role of inflammation in various diseases, from cardiovascular diseases to cancer, they can be used as therapeutic agents. What's more, increasing awareness in the area of proper nutrition and consumption of food rich in polyphenols may have a protective effect on human health.
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