Mouse Models in Aging Research

Publisher Summary In invertebrates, the molecular genetic pathways that regulate life span and senescence are being identified; surprisingly, they are conserved through evolution. In mice, specific genes that can increase life span have been identified, demonstrating that fundamental mechanisms of senescence may be alterable in mammals, as they are in lower organisms. Gerontologists are extending these discoveries to define the mechanisms of mammalian aging and to develop interventions—suitable for humans—that can keep humans healthier longer. Well-designed research, using mouse models appropriate to the unique needs of gerontologic studies, can expedite these goals. Over past decades, great progress has been made in gerontology by using genetically defined mice and specific pathogen free conditions. Continued refinement of optimal experimental design for gerontologic studies requires an astute choice of mouse models that limits the interference from endogenous disease and maximizes genetic diversity. With the development of experimental design strategies that focus on mechanisms of senescence, researchers refine their hypotheses of aging, narrow the search for its causes, and discover effective interventions.