适体
指数富集配体系统进化
纳米材料
免疫原性
纳米技术
核酸
灵活性(工程)
SELEX适体技术
癌症治疗
癌症
材料科学
化学
生物
分子生物学
免疫系统
核糖核酸
生物化学
免疫学
基因
统计
遗传学
数学
作者
Hong-Min Meng,Ting Fu,Xiaobing Zhang,Weihong Tan
摘要
Abstract Nucleic acid aptamers, which are generated by a novel technique called SELEX (systematic evolution of ligands by exponential enrichment), have recently attracted significant attention in the field of early detection and treatment of cancer based on their numerous merits, such as high affinity, high specificity, small size, little immunogenicity, stable structures, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, carbon nanomaterials, DNA nanodevices, and polymeric nanoparticles. We discuss the progress achieved in cancer diagnosis and therapy through the conjugation of cell-SELEX-based aptamers with different nanomaterials.
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