医学
造血干细胞移植
寻常性天疱疮
耐火材料(行星科学)
干细胞
移植
条件作用
免疫学
内科学
胃肠病学
生物
数学
遗传学
天体生物学
统计
作者
I. M. Suslova,Demetrios S. Theodoropoulos,Nicole Cullen,Maria K Tetarnikova,A. S. Tetarnikov,Nikolai A Kolchak
摘要
Objectives: Successful treat- ment of severe, refractory Pemphigus vulgaris (PV) is reported. Methods: Reduced intensity, non-myeloabla- tive conditioning was employed, followed by al- logeneic hematopoietic stem cell transplantation (HSCT) from a fully matched sibling. Results: Treatment of refractory PV with mye- loablation and subsequent allogenic HSCT has been previously reported, and sustained remis- sion with this approach has been achieved. Toxi- city, however, related to condition regimens re- mains high. Conclusion: Since no cytotoxic chemothera- py was used, it is hereby hypothesized that clini- cal improvement may result from regulatory ac- tion from the donor's marrow: a graft modifying the disease effect, which may prove useful in the management of autoimmune diseases.
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