蛋白质稳态
高铁F1
生物
癌症
基因组不稳定性
癌细胞
蛋白质组
细胞生物学
癌症研究
热休克蛋白
生物信息学
遗传学
热休克蛋白70
DNA损伤
基因
DNA
作者
Chengkai Dai,Stephen B. Sampson
标识
DOI:10.1016/j.tcb.2015.10.011
摘要
Proteomic instability is causally related to human diseases. In guarding proteome stability, the heat shock factor 1 (HSF1)-mediated proteotoxic stress response plays a pivotal role. Contrasting with its beneficial role of enhancing cell survival, recent findings have revealed a compelling pro-oncogenic role for HSF1. However, the mechanisms underlying the persistent activation and function of HSF1 within malignancy remain poorly understood. Emerging evidence reveals that oncogenic signaling mobilizes HSF1 and that cancer cells rely on HSF1 to avert proteomic instability and repress tumor-suppressive amyloidogenesis. In aggregate, these new developments suggest that cancer cells endure chronic proteotoxic stress and that proteomic instability is intrinsically associated with the malignant state, a characteristic that could be exploited to combat cancer.
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