生物
密码子使用偏好性
遗传学
选择(遗传算法)
翻译(生物学)
遗传漂变
同义替换
人口
突变
中性突变
基因
突变率
无声突变
稳定选择
自然选择
否定选择
进化生物学
遗传变异
计算机科学
基因组
信使核糖核酸
错义突变
社会学
人口学
人工智能
出处
期刊:Genetics
[Oxford University Press]
日期:1991-11-01
卷期号:129 (3): 897-907
被引量:1000
标识
DOI:10.1093/genetics/129.3.897
摘要
Abstract It is argued that the bias in synonymous codon usage observed in unicellular organisms is due to a balance between the forces of selection and mutation in a finite population, with greater bias in highly expressed genes reflecting stronger selection for efficiency of translation. A population genetic model is developed taking into account population size and selective differences between synonymous codons. A biochemical model is then developed to predict the magnitude of selective differences between synonymous codons in unicellular organisms in which growth rate (or possibly growth yield) can be equated with fitness. Selection can arise from differences in either the speed or the accuracy of translation. A model for the effect of speed of translation on fitness is considered in detail, a similar model for accuracy more briefly. The model is successful in predicting a difference in the degree of bias at the beginning than in the rest of the gene under some circumstances, as observed in Escherichia coli, but grossly overestimates the amount of bias expected. Possible reasons for this discrepancy are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI