CCR2型
趋化因子受体
趋化因子
趋化因子受体
CCR1
药理学
化学
趋化性
受体
趋化因子受体CCR5
CCL7型
CCR3
CXCL2型
CCL13型
炎症
CCL5
作者
Henning W. Zimmermann,Viktor Sterzer,Hacer Şahin
标识
DOI:10.2174/1568026614666140827144115
摘要
Chemokines constitute a family of small heparin-binding proteins which orchestrate the infiltration of leukocytes during inflammation, but also directly influence other physiological and pathophysiological processes. In humans, more than 40 chemokines are known binding to around 18 G-protein-coupled receptors. A non-redundant role of certain chemokines and their receptors has been identified within the last years in inflammation and host defense. Among chemokine receptors, the CC chemokine receptors CCR1 and CCR2 have been shown to play a crucial role in these processes. Importantly, these receptors have already been targeted by specific antagonists in early human trials for autoimmune and infectious diseases. Although most of these antagonists failed to show any significant efficacy in the clinic, the knowledge of their biological effects could henceforth offer new avenues with optimal strategies for producing successful therapeutics.
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