Notch信号通路
薯蓣皂甙元
细胞生物学
细胞内
巨噬细胞
染色体易位
化学
槽口1
信号转导
癌症研究
生物
生物化学
体外
基因
有机化学
作者
Ambika Binesh,Sivasithambaram Niranjali Devaraj,Halagowder Devaraj
出处
期刊:Biochimie
[Elsevier]
日期:2018-05-01
卷期号:148: 63-71
被引量:22
标识
DOI:10.1016/j.biochi.2018.02.011
摘要
Notch signaling plays a pivotal role in homeostasis and cardiovascular development. The role of notch signaling in atherosclerosis cannot be complete without analysing the key role of notch in macrophages, which trigger the inflammatory response and subsequent plaque formation in atherosclerosis. Diosgenin showed its anti-atherosclerotic property by the unifying mechanism of suppressing the expression of notch signaling pathway, particularly the nuclear translocation of notch intracellular domain (NICD) in aorta and in differentiated macrophage cells. It is further confirmed by the inhibition of NICD by DAPT (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester), which also restricted the differentiation of macrophage. Hence, inhibition of nuclear translocation of NICD by diosgenin aids in preventing atherosclerosis.
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