The Tandem Claisen Rearrangement in Organic Synthesis

Background: Claisen rearrangement is an important reaction, and some "variants" are brought out under the inspiration of Claisen reaction, e.g. Bellus-Claisen rearrangement, Eschenmoser-Claisen rearrangement, Ireland-Claisen rearrangement, and Johnson-Claisen rearrangement. Objective: The application of tandem Claisen rearrangement in organic synthesis was analyzed and discussed herein. Method: We chose some important synthetic studies utilizing the tandem Claisen rearrangement as the key transformation and concisely described and discussed their contents. Results: The tandem reaction could shorten the reaction steps and improve the reaction yield. Conclusion: So, the tandem Claisen rearrangement would greatly improve the efficiency of reaction. Keywords: Tandem Claisen rearrangement, variants, organic synthesis, reaction step, efficiency, application.