化学
CD40
小分子
免疫系统
细胞毒性
T细胞
体外
细胞生物学
细胞毒性T细胞
生物化学
免疫学
生物
作者
Jinshui Chen,Yun Gyu Song,Damir Bojadzic,Alejandro Tamayo‐Garcia,Ana Marie Landin,Bonnie B. Blomberg,Péter Buchwald
标识
DOI:10.1021/acs.jmedchem.7b01154
摘要
Costimulatory interactions are required for T cell activation and development of an effective immune response; hence, they are valuable therapeutic targets for immunomodulation. However, they, as all other protein-protein interactions, are difficult to target by small molecules. Here, we report the identification of novel small-molecule inhibitors of the CD40-CD40L interaction designed starting from the chemical space of organic dyes. For the most promising compounds such as DRI-C21045, activity (IC
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