神经保护
缺氧(环境)
缺血
神经科学
医学
脑缺血
脑损伤
神经胶质
药理学
中枢神经系统
生物
化学
内科学
有机化学
氧气
作者
Sofía Mucci,María Inés Herrera,George E. Barreto,Rodolfo Kölliker-Frers,Francisco Capani
标识
DOI:10.2174/1381612823666170727145422
摘要
Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action.
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