化学
点击化学
工具箱
共价键
纳米技术
转化式学习
功能(生物学)
宏
超分子化学
组合化学
分子
动态共价化学
计算机科学
有机化学
程序设计语言
材料科学
生物
进化生物学
教育学
心理学
作者
Peyton Shieh,Megan R. Hill,Wenxu Zhang,Samantha L. Kristufek,Jeremiah A. Johnson
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-04-06
卷期号:121 (12): 7059-7121
被引量:101
标识
DOI:10.1021/acs.chemrev.0c01282
摘要
In the two decades since the introduction of the "click chemistry" concept, the toolbox of "click reactions" has continually expanded, enabling chemists, materials scientists, and biologists to rapidly and selectively build complexity for their applications of interest. Similarly, selective and efficient covalent bond breaking reactions have provided and will continue to provide transformative advances. Here, we review key examples and applications of efficient, selective covalent bond cleavage reactions, which we refer to herein as "clip reactions." The strategic application of clip reactions offers opportunities to tailor the compositions and structures of complex (bio)(macro)molecular systems with exquisite control. Working in concert, click chemistry and clip chemistry offer scientists and engineers powerful methods to address next-generation challenges across the chemical sciences.
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