Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)

医学 四分位数 逻辑回归 脑出血 内科学 冲程(发动机) 酒精摄入量 多中心研究 糖尿病 病例对照研究 胃肠病学 置信区间 内分泌学 蛛网膜下腔出血 化学 工程类 机械工程 生物化学
作者
Martina Locatelli,Mario Grassi,Valentina Saba,Licia Iacovello,Augusto Di Castelnuovo,Giovanni de Gaetano,Marialuisa Zedde,Simona Marcheselli,Giorgio Silvestrelli,Alfonso Ciccone,Maria Luisa DeLodovici,Lucia Princiotta Cariddi,Alessia Giossi,Andrea Zini,Maurizio Paciaroni,Monica Acciarresi,Cristiano Azzini,Alessandro De Vito,Massimo Gamba,Mauro Magoni,Massimo Del Sette,Antonella Toriello,Carlo Gandolfo,Cinzia Finocchi,Domenico Marco Bonifati,Rossana Tassi,Giuseppe Martini,Anna Cavallini,Andrea Morotti,Sonia Bonacina,Valentina Mazzoleni,Debora Pezzini,Alberto Chiti,Rocco Salvatore Calabrò,Rosa Musolino,Paolo La Spina,Francesco Grillo,Giampaolo Tomelleri,Corrado Lodigiani,Marco Ritelli,Marina Colombi,Alessandro Padovani,Alessandro Pezzini
出处
期刊:Journal of Neurology, Neurosurgery, and Psychiatry [BMJ]
卷期号:: jnnp-325648
标识
DOI:10.1136/jnnp-2020-325648
摘要

To investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).We performed a case-control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1-Q4).We analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).Our findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.
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