杰纳斯
介孔材料
纳米颗粒
材料科学
纳米技术
介孔二氧化硅
乳状液
介孔有机硅
化学工程
化学
有机化学
催化作用
工程类
作者
Tiancong Zhao,Liang Chen,Minchao Liu,Runfeng Lin,Weiluo Cai,C. T. Hung,Shangfeng Wang,Linlin Duan,Fan Zhang,Ahmed A. Elzatahry,Xiaomin Li,Dongyuan Zhao
出处
期刊:Research Square - Research Square
日期:2021-10-25
标识
DOI:10.21203/rs.3.rs-960508/v1
摘要
Abstract Mesoporous Janus nanoparticles, due to the independent mesoporous compartments, tunable spatial isolated surfaces and compositions, have great application potentials in establishing biological logic systems. However, the reported Janus nanoparticles without large pores are incompatible for the loading of large bio-molecules, limiting their usages as biological logic gates. Herein, an emulsion-oriented assembly approach is demonstrated for the fabrication of highly-uniform Janus double-spherical MSN&mPDA (MSN = mesoporous silica nanoparticle, mPDA = mesoporous polydopamine) nanoparticles with dual large and tunable mesopores. In this novel approach, oil droplets first interact with MSNs to form double-spherical structures, and then orient the selective-encapsulation of mPDA, leading to the final Janus double-spherical MSN&mPDA nanoparticles. The delicate Janus nanoparticle possesses a spherical MSN with a uniform size of ~ 150 nm in diameter, and a mPDA hemisphere with a diameter of ~ 120 nm. The dual-mesoporous nanoparticles possess surface area of ~ 250 m 2 g −1 and also a high pore volume of ~ 0.56 cm 3 g −1 . In addition, the mesopore size in MSN compartment is tunable from ~ 3 to ~ 25 nm, while the mPDA compartments possess mesopores with the diameter ranging from ~ 5 to ~ 50 nm. Due to varied chemical properties and mesopore sizes in the two compartments, selective loading of guests in different compartments of the Janus mesoporous nanoparticles can be achieved. Based on such selective loading, single-particle-level biological logic gates with YES, OR and AND logics have been successfully established for the first time. We believe such work paves the way for constructing advanced asymmetric nanomaterials and realizing complex stimuli-responsive systems.
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