环加成
亲核细胞
催化作用
组合化学
化学
亚甲基
基础(拓扑)
铜
有机化学
数学
数学分析
作者
Jinhuan Dong,Wanzhong Feng,Lei Wang,Mei Li,Zhe Chen,Xianxiu Xu
摘要
An efficient, straightforward and general method for the de novo synthesis of highly functionalized 4-fluoropyridines was developed via a cooperative copper- and base-catalyzed [3+3] cycloaddition of active methylene isocyanides with difluorocyclopropenes. The resulting 4-fluoropyridines can be readily diversified by various nucleophiles.
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