Effect of chemotherapy with alkylating agents on the yield of CD34+ cells in patients with multiple myeloma. Results of the Spanish Myeloma Group (GEM) Study.

多发性骨髓瘤 化疗 医学 川地34 肿瘤科 内科学 粒细胞集落刺激因子 祖细胞 造血 干细胞 骨髓 造血干细胞移植 自体干细胞移植 移植 外科 泌尿科 生物 遗传学
作者
Javier de la Rubia,Joan Bladé,Lahuerta Jj,Josep‐María Ribera,Rafael Martínez,Adrián Alegre,José García‐Laraña,Pascual Fernández,Anna Sureda,de Arriba F,D. Carrera,Joan Besalduch,García Boyero R,Palomera Bernal L,Hernández Mt,García Siguero Pr,Javier Pérez‐Calvo,A Alcalá,Casado Lf,Jesús F. San Miguel
出处
期刊:PubMed 卷期号:91 (5): 621-7 被引量:54
链接
标识
摘要

Although alkylating agents are clearly beneficial in multiple myeloma (MM), their deleterious effect on bone marrow hematopoietic progenitor cells usually precludes their use as front-line therapy in patients scheduled to undergo autologous stem cell transplantation (ASCT). We analyzed the impact of first-line chemotherapy with alkylating agents on stem cell collection in MM patients.Seven hundred and eighty-nine patients included in the Spanish multicenter protocol GEM-2000 underwent mobilization therapy after four courses of alternating VBMCP/VBAD chemotherapy.The mobilization regimens consisted of standard or high-dose granulocyte colony-stimulating factor (G-CSF) in 551 (70%) patients, and chemotherapy and G-CSF in 206 (26%) patients. The CD34+ cell yield was lower than 4x10(6)/kg in 388 patients (49%), and equal or greater than 4x10(6)/kg in 401 patients (51%). Multivariate analysis indicated that advanced age (p<0.0001) and longer interval between diagnosis and mobilization (p=0.012) were the two variables associated with a lower CD34+ cell yield. Significant differences in CD34+ cell yield were not observed between the mobilization regimens. Of the 789 patients included in the protocol, 726 (92%) underwent the planned ASCT, whereas 25 (3%) patients did not because of the low number of CD34+ cells collected. Following ASCT, 0.5x10(9) neutrophils/L could be recovered after 11 days (median time; range, 5-71 days) and 20x10(9) platelets/L could be recovered after 12 days (median time; range, 6-69 days).A short-course of therapy with alkylating agents according to the GEM-2000 protocol was associated with an appropriate CD34+ cell collection, and allowed the planned ASCT to be performed in the majority of MM patients.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Jasper应助精明寻梅采纳,获得10
刚刚
米线儿完成签到,获得积分10
1秒前
甜桃完成签到,获得积分10
1秒前
1秒前
2秒前
CAOHOU应助q792309106采纳,获得10
2秒前
3秒前
3秒前
悦耳静枫发布了新的文献求助10
5秒前
烟花应助果粒多采纳,获得10
5秒前
潘善若发布了新的文献求助10
6秒前
廉凌波发布了新的文献求助10
6秒前
赘婿应助crazy采纳,获得10
6秒前
喻义梅关注了科研通微信公众号
7秒前
精明寻梅完成签到,获得积分10
7秒前
行远完成签到,获得积分10
8秒前
科目三应助感动黄豆采纳,获得10
9秒前
xueyu发布了新的文献求助10
9秒前
钱宇成完成签到,获得积分20
10秒前
修道院的豌豆完成签到,获得积分10
10秒前
廉凌波完成签到,获得积分10
11秒前
Rondab应助行远采纳,获得10
13秒前
13秒前
SYLH应助showmaker采纳,获得20
14秒前
14秒前
领导范儿应助FXQ123_范采纳,获得10
14秒前
Afaq完成签到,获得积分20
15秒前
油饼发布了新的文献求助30
17秒前
潘善若发布了新的文献求助10
17秒前
ganxinran发布了新的文献求助10
17秒前
19秒前
19秒前
21秒前
果粒多发布了新的文献求助10
24秒前
可爱的函函应助大刘采纳,获得10
25秒前
Rondab应助q792309106采纳,获得10
25秒前
25秒前
momo发布了新的文献求助10
26秒前
潘善若发布了新的文献求助10
27秒前
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989263
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253814
捐赠科研通 3270066
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136