材料科学
癌症免疫疗法
纳米团簇
肿瘤微环境
纳米技术
免疫疗法
牛血清白蛋白
CD8型
干扰素基因刺激剂
肝细胞癌
免疫系统
先天免疫系统
癌症研究
生物
免疫学
作者
Dong Cen,Qiwei Ge,Congkun Xie,Qiang Zheng,Jiansheng Guo,Yuqi Zhang,Yifan Wang,Xiang Li,Zhen Gu,Xiujun Cai
标识
DOI:10.1002/adma.202104037
摘要
Abstract Although immunotherapy such as immune checkpoint inhibitors has shown promising efficacy in cancer treatment, the responsiveness among patients is relatively limited. Activation of the cyclic guanosine monophosphate‐adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity has become an emerging strategy for enhancing tumor immunotherapy. Herein, ZnS@BSA (bovine serum albumin) nanoclusters synthesized via a self‐assembly approach are reported, where the released zinc ions under acidic tumor microenvironment significantly enhance cGAS/STING signals. Meanwhile, intracellular zinc ions can produce reactive oxygen species, which is further facilitated by the generated H 2 S gas from ZnS@BSA via specifically inhibiting catalase in hepatocellular carcinoma cells. It is found that the nanoclusters activate the cGAS/STING signals in mice, which promotes the infiltration of CD8 + T cells at the tumor site and cross‐presentation of dendritic cells, leading to an improved immunotherapy efficacy against hepatocellular carcinoma.
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