生物膜
一氧化氮
伤口愈合
化学
微生物学
抗菌剂
细菌
细胞毒性
生物化学
外科
体外
生物
医学
有机化学
遗传学
作者
Mengna Li,Na Li,Weiwang Qiu,Qian Wang,Jie Jia,Xueli Wang,Jianyong Yu,Xiaoran Li,Faxue Li,Dequn Wu
标识
DOI:10.1016/j.jcis.2021.10.016
摘要
Infected wounds show delayed and incomplete healing processes and even render patients at a high risk of death due to the formed bacterial biofilms in the wound site, which protect bacteria against antimicrobial treatments and immune response. Nitric oxide based therapy is considered a promising strategy for eliminating biofilms and enhancing wound healing, which encounters a significant challenge of controlling the NO release behavior at the wound site. Herein, a kind of phenylalanine based poly(ester urea)s with high thermal stability are synthesized and fabricated to electrospun films as NO loading vehicle for infected wound treatment. The resultant films can continuously and stably release nitric oxide for 360 h with a total concentration of 1.15 μmol L-1, which presents obvious advantages in killing the bacteria and removing biofilms. The results exhibit the films have no cytotoxicity and may accelerate the wound repair without causing inflammation, hemolysis, or cytotoxic reactions as well as stimulate the proliferation of fibroblasts and increase the synthesis of collagen. Therefore, the films may be a suitable NO releasing dressing for removing biofilms and repairing infected wounds.
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