Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Adults with Moyamoya Disease

医学 烟雾病 磁共振成像 高强度 内科学 逻辑回归 神经学 单变量分析 白质疏松症 临床意义 心脏病学 放射科 多元分析 精神科
作者
Haogeng Sun,Wanjiang Li,Chao Xia,Yutao Ren,Lu Ma,Anqi Xiao,Chao You,Xiaoyu Wang,Rui Tian,Yi Liu
出处
期刊:Translational Stroke Research [Springer Science+Business Media]
卷期号:13 (4): 533-542 被引量:12
标识
DOI:10.1007/s12975-021-00973-7
摘要

In clinical work, the magnetic resonance imaging markers of cerebral small vessel disease (CSVD) are frequently observed in moyamoya disease (MMD), but the clinical significance of these markers in MMD remains unclear. This study aimed to fill this gap and systematically investigate its clinical significance. In this retrospective cohort study, we screened all adult patients with MMD hospitalized from January 2016 to January 2020 and collected their baseline clinical and imaging information. Univariate and multivariate logistic regression analyses were then performed to determine which imaging markers were independently associated with MMD characteristics, including cerebrovascular morphology, cerebral hemodynamics, cerebrovascular events, and postoperative collateral formation (PCF). A total of 312 cerebral hemispheres images were collected from the 156 patients with MMD. Using multivariate logistic regression analysis, the following results were generated: (1) The presence of lacunes (OR, 2.094; 95% CI, 1.109–3.955; p = 0.023) and severe white matter hyperintensities (WMH) (OR, 3.204; 95% CI, 1.742–5.892; p < 0.001) were associated with a Suzuki stage ≥ IV; (2) the presence of lacunes (OR, 6.939; 95% CI, 3.384–14.230; p < 0.001), higher numbers of enlarged perivascular spaces in centrum semiovale (CSO-EPVS) (OR, 1.046; 95% CI, 1.024–1.067; p < 0.001), and severe WMH (OR, 2.764; 95% CI, 1.463–5.223; p = 0.002) were associated with the reduced regional cerebral blood flow; (3) the presence of lacunes (OR, 12.570; 95% CI, 2.893–54.624; p = 0.001), higher numbers of CSO-EPVS (OR, 1.103; 95% CI, 1.058–1.150; p < 0.001), and severe WMH (OR, 5.982; 95% CI, 1.727–20.716; p = 0.005) were associated with ischemic cerebrovascular events; (4) the higher number of CSO-EPVS (OR, 1.077; 95% CI, 1.026–1.131; p = 0.003) was associated with good PCF. The lacunes, WMH, and CSO-EPVS were independently associated with these MMD characteristics. In conclusion, this study provided a novel and potential framework for the practical assessment of MMD by magnetic resonance imaging.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
qiancib202完成签到,获得积分10
1秒前
量子星尘发布了新的文献求助10
2秒前
等待的幼晴完成签到,获得积分10
3秒前
负责灵萱完成签到 ,获得积分10
5秒前
幽默的忆霜完成签到 ,获得积分10
13秒前
15秒前
19秒前
风光无限完成签到 ,获得积分20
23秒前
庄海棠完成签到 ,获得积分10
35秒前
量子星尘发布了新的文献求助10
36秒前
沐风完成签到 ,获得积分10
42秒前
含糊的茹妖完成签到 ,获得积分0
45秒前
50秒前
huangqian完成签到,获得积分10
55秒前
沧海一粟完成签到 ,获得积分10
58秒前
进击的巨人完成签到 ,获得积分10
1分钟前
1分钟前
牛马完成签到,获得积分10
1分钟前
1分钟前
我不是奶黄包完成签到,获得积分10
1分钟前
Gavin完成签到,获得积分10
1分钟前
cq_2完成签到,获得积分10
1分钟前
花生完成签到 ,获得积分10
1分钟前
小二郎应助科研通管家采纳,获得10
1分钟前
Hello应助科研通管家采纳,获得10
1分钟前
Tianling完成签到,获得积分0
1分钟前
Rn完成签到 ,获得积分10
1分钟前
吉祥高趙完成签到 ,获得积分10
1分钟前
嘉人完成签到 ,获得积分10
1分钟前
可千万不要躺平呀应助yar采纳,获得10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
Lucas应助尊敬代亦采纳,获得10
1分钟前
yinshan完成签到 ,获得积分10
1分钟前
1分钟前
yar重新开启了小飞文献应助
1分钟前
1分钟前
幸福的杨小夕完成签到,获得积分20
1分钟前
1分钟前
1分钟前
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038029
求助须知:如何正确求助?哪些是违规求助? 3575740
关于积分的说明 11373751
捐赠科研通 3305559
什么是DOI,文献DOI怎么找? 1819224
邀请新用户注册赠送积分活动 892652
科研通“疑难数据库(出版商)”最低求助积分说明 815022