喜树碱
阿霉素
赫拉
化学
介孔二氧化硅
药物输送
结合
连接器
光动力疗法
拓扑异构酶
体外
生物物理学
乙二醇
内吞作用
细胞毒性
PEG比率
盐酸阿霉素
毒品携带者
纳米颗粒
生物化学
纳米技术
材料科学
介孔材料
化疗
生物
细胞
有机化学
操作系统
财务
数学分析
遗传学
计算机科学
数学
催化作用
经济
作者
Gabriel Martínez‐Edo,Evelyn Y. Xue,Summer Y. Y. Ha,Iris Pontón,José A. González‐Delgado,Salvador Borrós,Tomás Torres⊗,Dennis K. P. Ng,David Sánchez‐García
标识
DOI:10.1002/chem.202101842
摘要
A pH-responsive drug delivery system (DDS) based on mesoporous silica nanoparticles (MSNs) has been prepared for the delivery of three anticancer drugs with different modes of action. The novelty of this system is its ability to combine synergistic chemotherapy and photodynamic therapy. A photoactive conjugate of a phthalocyanine (Pc) and a topoisomerase I inhibitor (topo-I), namely camptothecin (CPT), linked by a poly(ethylene glycol) (PEG) chain has been synthesized and then loaded into the mesopores of MSNs. Doxorubicin (DOX), which is a topoisomerase II inhibitor (topo-II), has also been covalently anchored to the outer surface of the MSNs through a dihydrazide PEG linker. In the acidic environment of tumor cells, selective release of the three drugs takes place. In vitro studies have demonstrated the endocytosis of the system into HeLa and HepG2 cells, and the subsequent release of the three drugs into the cytoplasm and nucleus. Furthermore, the cytotoxic effect of DOX, CPT and Pc has been assessed in vitro before and upon light irradiation.
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