色酮
赫拉
细胞毒性
立体化学
圆二色性
真菌
化学
青霉属
癌细胞
IC50型
体外
生物
生物化学
植物
食品科学
作者
Yulin Sun,Jie Bao,Kaisheng Liu,Xiaoyong Zhang,Fei He,Yifei Wang,Xu‐Hua Nong,Shihua Qi
出处
期刊:Planta Medica
[Georg Thieme Verlag KG]
日期:2013-09-13
卷期号:79 (15): 1474-1479
被引量:51
标识
DOI:10.1055/s-0033-1350805
摘要
Two new dihydrothiophene-condensed chromones and a new natural chromone, namely oxalicumones A-C (1-3), respectively, were isolated from a culture broth of a marine-derived fungus, Penicillium oxalicum. The structures of 1-3 and acetylated derivatives of 1 (4-7) were elucidated on the basis of spectroscopic methods and chemical reactions. The absolute configuration of 1 and 2 were established by using the modified Mosher ester method and circular dichroism data of an in situ formed [Rh2(OCOCF3)4] and [Mo2(OAc)4] complex. (R)-MTPA ester of 1 showed cytotoxicity against A375, SW-620, and HeLa carcinoma cell lines with IC50 values of 8.9, 7.8, and 18.4 µM, respectively. Compound 1 displayed cytotoxicity against A375 and SW-620 cell lines with IC50 values of 11.7 and 22.6 µM, respectively. The structure-biological activity relationship of 1 was discussed.
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