Metabolites of Endophytic Fungus Fusarium sp.F4 from Spartina alterniflora

AIM:To study the metabolites of endophytic fungus Fusarium sp.F4,which was isolated from seagrass Spartina alterniflora.METHOD:Compounds were isolated by column chromatography(silica gel,Sephadex LH-20)and their structures were elucidated by spectroscopic analysis.RESULTS:Six compounds were obtained and identified as ergosterol(Ⅰ),ergosterol peroxide(Ⅱ),beauvericin(Ⅲ),T-2 toxin(Ⅳ),ilicicolin H(Ⅴ)and alcaligin(Ⅵ).CONCLUSION:Compounds V and Ⅵ were obtained from Genus Fusarium for the first time.1H NMR data of Ⅴ were total assignmented based on 1H-1H COSY and HMBC.Compound Ⅲ showed significant inhibition to Mycorbacterium tuberculosis H37RV.