纳米技术
材料科学
纳米线
传感器
表面改性
靶向给药
药物输送
声学
化学
物理
物理化学
作者
Víctor García‐Gradilla,Jahir Orozco,Sirilak Sattayasamitsathit,Fernando Soto,Filiz Kuralay,Ashley Pourazary,Adlai Katzenberg,Wei Gao,Yufeng Shen,Joseph Wang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2013-08-28
卷期号:7 (10): 9232-9240
被引量:379
摘要
Magnetically guided ultrasound-powered nanowire motors, functionalized with bioreceptors and a drug-loaded polymeric segment, are described for “capture and transport” and drug-delivery processes. These high-performance fuel-free motors display advanced capabilities and functionalities, including magnetic guidance, coordinated aligned movement, cargo towing, capture and isolation of biological targets, drug delivery, and operation in real-life biological and environmental media. The template-prepared three-segment Au–Ni–Au nanowire motors are propelled acoustically by mechanical waves produced by a piezoelectric transducer. An embedded nickel segment facilitates a magnetically guided motion as well as transport of large “cargo” along predetermined trajectories. Substantial improvement in the speed and power is realized by the controlled concavity formation at the end of the motor nanowire using a sphere lithography protocol. Functionalization of the Au segments with lectin and antiprotein A antibody bioreceptors allows capture and transport of E. coli and S. aureus bacteria, respectively. Potential therapeutic applications are illustrated in connection to the addition of a pH-sensitive drug-loaded polymeric (PPy-PSS) segment. The attractive capabilities of these fuel-free acoustically driven functionalized Au–Ni–Au nanowires, along with the simple preparation procedure and minimal adverse effects of ultrasonic waves, make them highly attractive for diverse in vivo biomedical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI