生物
先天免疫系统
干扰素
信号转导衔接蛋白
细胞生物学
转录因子
甲型流感病毒
病毒
病毒学
免疫系统
Ⅰ型干扰素
信号转导
基因
免疫学
遗传学
作者
Carolin Nordhoff,Andrea Hillesheim,Beate M. Walter,Emanuel Haasbach,Oliver Planz,Christina Ehrhardt,Stephan Ludwig,Viktor Wixler
标识
DOI:10.1111/j.1462-5822.2012.01787.x
摘要
The innate immune response of influenza A virus-infected cells is predominantly mediated by type I interferon-induced proteins. Expression of the interferon β (IFNβ) itself is initiated by accumulating viral RNA and is transmitted by different signalling cascades that feed into activation of the three transcriptional elements located in the IFNβ promoter, AP-1, IRF-3 and NF-κB. FHL2 (four-and-a-half LIM domain protein 2) is an adaptor molecule that shuttles between membrane and nucleus regulating signalling cascades and gene transcription. Here we describe FHL2 as a novel regulator of influenza A virus propagation. Using mouse FHL2 wild-type, knockout and rescued cells and human epithelial cells with different expression levels of FHL2 we showed that FHL2 decreases influenza A virus propagation by regulating the intrinsic cellular antiviral immune response. On virus infection FHL2 translocates into the nucleus, potentiating the IRF-3-dependent transcription of the IFNβ gene.
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