Reference Range of Vitamin K Evaluating Indicators in Chinese Childbearing Women

参考范围 骨钙素 基质gla蛋白 医学 维生素 人口 生理学 内分泌学 内科学 化学 生物化学 碱性磷酸酶 环境卫生 高磷血症 肾脏疾病
作者
Shuhui Nie,Lichen Yang,Jie Feng,Jiaxi Lu,Huidi Zhang,Weidong Li,Yichun Hu,Xiaoguang Yang
出处
期刊:Nutrients [MDPI AG]
卷期号:15 (8): 1977-1977 被引量:5
标识
DOI:10.3390/nu15081977
摘要

Background: Vitamin K is an essential fat-soluble vitamin for the human body and its functions, such as promoting blood coagulation, bone health and preventing atherosclerosis, have attracted increasing attention. However, there is no recognized indicator and corresponding reference range for evaluating vitamin K status of different populations at present. The aim of this study is to establish a reference range for vitamin K evaluating indicators in healthy women of childbearing age in China. Methods: The population sample in this study was from the Chinese Adult Chronic Disease and Nutrition Surveillance (CACDNS) 2015–2017. A total of 631 healthy women of childbearing age (18–49 years) were included using a series of strict inclusion and exclusion criteria. The concentrations of VK1, MK-4 and MK-7 in serum were detected by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The other commonly-reported indicators evaluating vitamin K nutritional status, including undercarboxylated osteocalcin (ucOC), osteocalcin (OC), matrix Gla protein (MGP), desphosphorylated undercaboxylated MGP (dp-ucMGP) and protein induced by vitamin K absence II (PIVKA-II), were measured by enzyme-linked immunosorbent assay (ELISA). The reference range was obtained by calculating the 2.5% to 97.5% interval of the vitamin K evaluating indicators in the reference population. Results: The reference ranges of VK1, MK-4 and MK-7 in serum were 0.21–3.07 ng/mL, 0.02–0.24 ng/mL and 0.12–3.54 ng/mL, respectively. The reference ranges of ucOC, %ucOC, dp-ucMGP and PIVKA-II were 1.09–2.51 ng/mL, 5.80–22.78%, 2.69–5.88 ng/mL and 3.98–8.40 ng/mL, respectively. The cut-off values that can be used to evaluate subclinical vitamin K deficiency were as follows: VK1 < 0.21 ng/mL, MK-7 < 0.12 ng/mL, ucOC > 2.51 ng/mL, %ucOC > 22.78%, dp-ucMGP > 5.88 ng/mL and PIVKA-II > 8.40 ng/mL. Conclusion: The reference range of VK1, MK-4, MK-7 and vitamin K-related indicators for healthy women of childbearing age established in this study could be used to assess the nutritional and health status of this population.
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