Proton Pump Inhibitors and Acute Kidney Injury After Cardiac Surgery

Koh et al1 showed an association between preoperative proton pump inhibitor (PPI) and acute kidney injury (AKI) after cardiac surgery, including coronary artery bypass grafting (CABG) and open-heart valve repair or replacement surgery. We find their findings intriguing because preoperative PPI exposure can be avoided before the onset of AKI, but we would like to debate a few points with the authors.