The evidence framework of traditional Chinese medicine injection (Aidi injection) in controlling malignant pleural effusion: A clustered systematic review and meta-analysis

医学 恶性胸腔积液 胸膜成形术 内科学 荟萃分析 胸腔积液 中医药 随机对照试验 肿瘤科 病理 替代医学
作者
Cheng-Qiong Wang,Jiao Xu,Hong Jiang,Xiao-Tian Zheng,Yan Zhang,Xiao-Rong Huang,Fei She,Teng-Yang Fan,Lin Zhan,Jihong Feng,Qihai Gong,Xue Xiao,Xiaofan Chen,Zheng Xiao
出处
期刊:Phytomedicine [Elsevier BV]
卷期号:115: 154847-154847 被引量:2
标识
DOI:10.1016/j.phymed.2023.154847
摘要

Aidi injection (Aidi), a traditional Chinese medicine injection, is often practiced to control malignant pleural effusion (MPE). We performed a registered systematic review and meta-analysis (PROSPERO: CRD42022337611) to clarify the clinical role of Aidi in MPE, reveal optimal combinations of Aidi and chemical agents, their indications, therapeutic route and usage, and demonstrate their clinical effectiveness and safety. All randomized controlled trials (RCTs) about Aidi in controlling MPE were collected from Chinese and English databases (up to October 2022). We clustered them into multiple homogenous regimens, evaluated the risk-of-bias at outcome level using a RoB 2, extracted and pooled the data using meta-analysis or descriptive analysis, and finally summarized their evidence quality. All 56 studies were clustered into intrapleural administration with Aidi alone or plus chemical agents, and intravenous administration with Aidi for MPE. Intrapleural administration with Aidi alone displayed similar clinical responses on Cisplatin (DDP) alone. Only administration with Aidi plus DDP significantly improved complete response and quality of life, and displayed a low pleurodesis failure, disease progression, hematotoxicity, gastrointestinal and hepatorenal toxicity. For patients with moderate to massive effusion, Karnofsky Performance Status score ≥ 50 or anticipated survival time ≥3 months, Aidi (50 ml to 80 ml each time, one time each week and three to eight times) plus DDP (20 to 30 mg, 40 to 50 mg, or 60 to 80 mg each time) significantly improved clinical responses. Most results had moderate to low quality. Current evidences indicate that Aidi, a pleurodesis agent, plays an interesting clinical role in controlling MPE. Aidi plus DDP perfusion is a most commonly used regimen, which shows a significant improvement in clinical responses. These findings also provide an indication and possible optimal usage for rational drug use.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
充电宝应助yankai采纳,获得30
刚刚
1秒前
1秒前
11发布了新的文献求助10
1秒前
1秒前
高高发布了新的文献求助10
2秒前
jjj应助qq采纳,获得20
2秒前
2秒前
2秒前
3秒前
Yimi完成签到,获得积分10
4秒前
4秒前
5秒前
CHENCHEN完成签到,获得积分10
5秒前
6秒前
帅关发布了新的文献求助10
6秒前
7秒前
7秒前
hantuo发布了新的文献求助10
7秒前
LFC发布了新的文献求助10
8秒前
8秒前
科研韭菜发布了新的文献求助10
9秒前
充电宝应助jingyu841123采纳,获得10
11秒前
dearcih完成签到,获得积分10
12秒前
12秒前
13秒前
yankai发布了新的文献求助30
13秒前
小二郎应助木易采纳,获得10
13秒前
13秒前
帅关完成签到,获得积分10
13秒前
Akim应助马良伟采纳,获得10
13秒前
Owen应助细腻的歌曲采纳,获得10
14秒前
甜瓜不熟完成签到,获得积分10
15秒前
六六大顺发布了新的文献求助10
15秒前
喝下午茶的狗完成签到,获得积分10
16秒前
桐桐应助hantuo采纳,获得10
16秒前
16秒前
17秒前
17秒前
18秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969513
求助须知:如何正确求助?哪些是违规求助? 3514327
关于积分的说明 11173617
捐赠科研通 3249672
什么是DOI,文献DOI怎么找? 1794973
邀请新用户注册赠送积分活动 875537
科研通“疑难数据库(出版商)”最低求助积分说明 804836