[Advances of TRIM superfamily proteins in chronic liver disease and hepatocellular carcinoma].

The modification of proteins with ubiquitination is closely related to the occurrence and development of chronic liver disease and hepatocellular carcinoma. The tripartite motif (TRIM) family of proteins is one of the E3 ubiquitin ligase subfamily, which participates in various biological processes such as intracellular signal transduction, apoptosis, autophagy, and immunity by regulating the ubiquitination of target proteins. A growing body of research shows that the TRIM family of proteins plays an important role in chronic liver disease. This article systematically reviews the role and molecular mechanism of TRIM protein in the process of chronic liver disease, with the aim of exploring its potential application in the clinical diagnosis and treatment.蛋白的泛素化修饰与慢性肝病及肝癌发生发展密切相关。三结构域（TRIM）蛋白家族是E3泛素连接酶亚家族之一，通过调控靶蛋白的泛素化，参与细胞内信号转导、凋亡、自噬和免疫等多种生物学过程。越来越多的研究表明，TRIM蛋白家族在肝病慢性化过程中起着重要作用。现对TRIM蛋白在慢性肝病进程中的作用及分子机制进行了系统综述，目的在于探讨其应用于肝脏疾病临床诊治的潜在前景。.