Rapid Clinical Remission With Upadacitinib in a Pediatric Patient With Refractory Crohn’s Disease

Lay Summary A pediatric patient with Crohn’s disease refractory to anti-tumor necrosis factor therapy, vedolizumab, ustekinumab, and 6-mercaptopurine achieved rapid clinical remission with upadacitinib. This is the first report of successful use of upadacitinib in pediatric inflammatory bowel disease.