先天免疫系统
胞浆
模式识别受体
生物
核心
免疫
干扰素
细胞生物学
计算生物学
免疫系统
免疫学
生物化学
酶
作者
Wenzhuo Hao,Wenjun Li,Lingyan Wang,Shitao Li
标识
DOI:10.1016/j.cytogfr.2023.09.004
摘要
The cyclic GMP-AMP synthase (cGAS) is a widely recognized pattern recognition receptor responsible for detecting pathogenic DNA in the cytosol and inducing the production of type I interferon (IFN) to combat infections. The recently discovered nuclear localization of cGAS has changed the old dogma, illuminated a captivating dimension of innate immunity, and sparked many fundamental questions beyond the field of immunology. This review explores cGAS nuclear localization models, activation mechanisms, and biological significance. This expansion challenges the conventional understanding of cGAS and opens new avenues for scientific exploration, promising insights into cellular surveillance and potentially unveiling new therapeutic targets for immune disorders.
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