肠道菌群
花青素
胆汁酸
脂多糖
促炎细胞因子
脂质代谢
炎症
肿瘤坏死因子α
生物
生物化学
新陈代谢
化学
内分泌学
免疫学
食品科学
作者
Qinqin Yu,F S Yu,Qiong Li,Jie Zhang,You Peng,Xiaoya Wang,Tao Li,Ning Yin,Genlin Sun,Hui Ouyang,Yuhuan Chen,Yoshinori Mine,Rong Tsao,Hua Zhang
标识
DOI:10.1021/acs.jafc.3c02696
摘要
This study aimed to explore the enhancive effects of butterfly pea flower (BF) extracts on metabolic and immune homeostasis in a low-grade inflammation mouse model. The BF extract was found to contain mainly anthocyanins among other flavonoids. BF supplementation alleviated metabolic endotoxemia by lowering the plasma glucose, lipopolysaccharide (LPS), and tumor necrosis factor-α (TNF-α) levels and restored lipid metabolism and the balance between Treg and Th17 cells, thereby inhibiting the dysfunctional liver and abdominal white adipose tissues. BF extract increased the tight junction protein expression and reduced the expression of proinflammatory cytokines, therefore sustaining the colonic mucosa structure. Furthermore, BF extracts reshaped the gut microbiota structure characterized by significantly promoted SCFA-producing gut microbiota such as Akkermansia and Butyricicoccaceae. Additionally, BF extracts enhanced fecal primary bile acid (BA) levels and modulated bile acid signaling in the liver and ileum to facilitate BA synthesis for the restoration of lipid metabolism. In summary, anthocyanin-enriched BF extracts alleviated the profound negative dietary alterations and helped maintain the metabolic health by modulating the various aspects of the gut microenvironment and enhancing hepatic bile acid synthesis.
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