银屑病
透皮
壳聚糖
自愈水凝胶
药品
药物输送
甲氨蝶呤
药理学
透皮贴片
材料科学
医学
生物医学工程
化学
纳米技术
皮肤病科
外科
有机化学
高分子化学
作者
Panpan Dai,Xing Ge,Caixia Sun,Hui Jiang,Wanchao Zuo,Pengcheng Wu,Cong Liu,Shuyue Deng,Jun Yang,Jianjun Dai,Yanmin Ju
标识
DOI:10.1002/mabi.202300194
摘要
Psoriasis is a chronic and recurrent skin disease that often requires long-term treatment, and topical transdermal drug delivery can reduce systemic side effects. However, it is still a challenge in efficient transdermal drug delivery for psoriasis treatment due to low penetration efficiency of most drugs and the abnormal skin conditions of psoriasis patients. Here, a safe and effective methacryloyl chitosan hydrogel microneedles (CSMA hMNs) patch is developed and served as a sustained drug release platform for the treatment of psoriasis. By systematically optimizing the CSMA preparation, CSMA hMNs with excellent morphological characteristics and strong mechanical properties (0.7 N needle-1 ) are prepared with a concentration of only 3% (w/v) CSMA. As a proof-of-concept, methotrexate (MTX) and nicotinamide (NIC) are loaded into CSMA hMNs patch, which can produce a sustained drug release of 80% within 24 h in vitro. In vivo experiments demonstrated that the CSMA hMNs patch can effectively inhibit the skin thickening and spleen enlargement of psoriatic mice and has a good biosafety profile at sufficient therapeutic doses. This study provides a new idea for the preparation of hMN systems using modified CS or other biocompatible materials and offers an effective therapeutic option for psoriasis treatment.
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