头颈部鳞状细胞癌
头颈部
基底细胞
细胞生长
癌症研究
生物
细胞凋亡
细胞生物学
表达式(计算机科学)
神经科学
内科学
医学
癌症
计算机科学
遗传学
头颈部癌
外科
程序设计语言
作者
Kunliang Luo,Xiangtong Zhao,Yu Shan,Xuewen Wang,Yaohan Xu,Ming Chen,Xian Wang,Yinjing Song
出处
期刊:Life Sciences
[Elsevier]
日期:2023-12-01
卷期号:334: 122191-122191
被引量:2
标识
DOI:10.1016/j.lfs.2023.122191
摘要
Gamma-aminobutyric acid (GABA) is a multifunctional molecule that is widely present in the nervous system and nonneuronal tissues. It plays pivotal roles in neurotransmission, regulation of secretion, cell differentiation, proliferation, and tumorigenesis. However, the exact mechanisms of GABA in head and neck squamous cell carcinomas (HNSCCs) are unknown. We took advantage of RNA sequencing in this work and uncovered the potential gene expression profiles of the GABA-treated HNSCC cell line HN4–2. We found that the expression of CCND2 and BCL2L1 was significantly upregulated. Furthermore, GABA treatment inhibited the cell apoptosis induced by cisplatin and regulated the cell cycle after treatment with cisplatin in HN4–2 cells. Moreover, we also found that GABA could upregulate the expression of CCND2 and BCL2L1 after treatment with cisplatin. Our results not only reveal the potential pro-tumorigenic effect of GABA on HNSCCs but also provide a novel therapeutic target for HNSCC treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI