Depth of sedation with dexmedetomidine increases transcranial magnetic stimulation-evoked potential amplitude non-linearly

右美托咪定 镇静 磁刺激 麻醉 无意识 后顶叶皮质 医学 诱发电位 清醒 皮质(解剖学) 脑电图 刺激 神经科学 心理学 内科学 听力学
作者
Paolo Cardone,Olivier Bodart,Muriëlle Kirsch,Julien Sanfilippo,Alessandra Virgillito,Charlotte Martial,Jessica Simon,Sarah Wannez,Robert D. Sanders,Steven Laureys,Marcello Massimini,Gilles Vandewalle,Vincent Bonhomme,Olivia Gosseries
出处
期刊:BJA: British Journal of Anaesthesia [Elsevier BV]
卷期号:131 (4): 715-725 被引量:3
标识
DOI:10.1016/j.bja.2023.05.030
摘要

Cortical excitability is higher in unconsciousness than in wakefulness, but it is unclear how this relates to anaesthesia. We investigated cortical excitability in response to dexmedetomidine, the effects of which are not fully known.We recorded transcranial magnetic stimulation (TMS) and EEG in frontal and parietal cortex of 20 healthy subjects undergoing dexmedetomidine sedation in four conditions (baseline, light sedation, deep sedation, recovery). We used the first component (0-30 ms) of the TMS-evoked potential (TEP) to measure cortical excitability (amplitude), slope, and positive and negative peak latencies (collectively, TEP indices). We used generalised linear mixed models to test the effect of condition, brain region, and responsiveness on TEP indices.Compared with baseline, amplitude in the frontal cortex increased by 6.52 μV (P<0.001) in light sedation, 4.55 μV (P=0.003) in deep sedation, and 5.03 μV (P<0.001) in recovery. Amplitude did not change in the parietal cortex. Compared with baseline, slope increased in all conditions (P<0.02) in the frontal but not parietal cortex. The frontal cortex showed 5.73 μV higher amplitude (P<0.001), 0.63 μV ms-1 higher slope (P<0.001), and 2.2 ms shorter negative peak latency (P=0.001) than parietal areas. Interactions between dexmedetomidine and region had effects over amplitude (P=0.004) and slope (P=0.009), with both being higher in light sedation, deep sedation, and recovery compared with baseline.Transcranial magnetic stimulation-evoked potential amplitude changes non-linearly as a function of depth of sedation by dexmedetomidine, with a region-specific paradoxical increase. Future research should investigate other anaesthetics to elucidate the link between cortical excitability and depth of sedation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小蘑菇应助风中的非笑采纳,获得10
刚刚
1秒前
1秒前
1秒前
微纳组刘同完成签到,获得积分10
1秒前
2秒前
2秒前
3秒前
123完成签到,获得积分10
3秒前
完美梨愁发布了新的文献求助10
4秒前
淡淡博完成签到 ,获得积分10
4秒前
wjxcl发布了新的文献求助10
4秒前
6秒前
sdl发布了新的文献求助10
6秒前
emmm完成签到 ,获得积分10
7秒前
十三发布了新的文献求助10
7秒前
8秒前
8秒前
liangmh完成签到,获得积分10
8秒前
一二不休完成签到,获得积分10
8秒前
123发布了新的文献求助10
9秒前
11秒前
ding应助黑熊安巴尼采纳,获得10
12秒前
Ava应助wjxcl采纳,获得10
12秒前
闪闪如南发布了新的文献求助10
12秒前
深情安青应助一二不休采纳,获得10
13秒前
15秒前
123完成签到,获得积分10
15秒前
不扯先生完成签到,获得积分10
16秒前
柳絮完成签到,获得积分20
17秒前
lll完成签到,获得积分10
17秒前
sdl完成签到,获得积分10
17秒前
Orange应助孟婆的碗采纳,获得10
18秒前
zhangmy1989发布了新的文献求助30
18秒前
18秒前
清秀的不言完成签到 ,获得积分10
18秒前
杂化轨道退役研究员完成签到,获得积分10
18秒前
FashionBoy应助tanglu采纳,获得10
19秒前
20秒前
闪闪如南完成签到,获得积分10
21秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048