Near-Infrared Spectroscopy to Guide and Understand Effects of Red Blood Cell Transfusion

This review is a summary of available evidence regarding the use of near-infrared spectroscopy (NIRS) to help better guide and understand the effects of red blood cell (RBC) transfusion in neonatal patients. We review recent literature demonstrating the changes that take place in regional tissue oxygen saturation (rSO 2 ) resulting from RBC transfusion. We also discuss in detail if any correlation exists between rSO 2 and hemoglobin values in neonates. Finally, we review studies that have evaluated the use of NIRS as a transfusion guide during neonatal intensive care .