中性粒细胞胞外陷阱
卵巢早衰
医学
发病机制
炎症
免疫系统
免疫学
维生素D与神经学
氧化应激
纤维化
内分泌学
内科学
作者
Menglu Chen,Lailai Li,Yihui Chai,Yuqi Yang,Sibu Ma,Xiang Pu,Yunzhi Chen
出处
期刊:Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2023-03-31
卷期号:102 (13): e33417-e33417
被引量:4
标识
DOI:10.1097/md.0000000000033417
摘要
The etiology of premature ovarian failure (POF) is mainly related to inflammatory diseases, autoimmune diseases, and tumor radiotherapy and chemotherapy; however, its specific pathogenesis has not been clarified. Vitamin D (VD), a fat-soluble vitamin, is an essential steroid hormone in the human body. Neutrophil extracellular traps (NETs) are meshwork structures that are formed when neutrophils are stimulated by inflammation and other factors and are closely associated with autoimmune and inflammatory diseases. Notably, VD inhibits NET formation and intervenes in the development of POF in terms of inflammatory and immune responses, oxidative stress, and tissue fibrosis. Therefore, this study aimed to theorize the relationship between NETs, VD, and POF and provide new ideas and targets for the pathogenesis and clinical treatment of POF.
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