Controlled therapeutic delivery of CO from carbon monoxide-releasing molecules (CORMs)

纳米载体 球茎 一氧化碳 化学 吸入 药物输送 药理学 组合化学 医学 生物化学 生物 有机化学 催化作用 麻醉 农学
作者
Ho-Ik Choi,Alam Zeb,Minsu Kim,Isra Rana,Namrah Khan,Omer Salman Qureshi,Chang-Wan Lim,Jeong Sook Park,Zhonggao Gao,Han‐Joo Maeng,Jin‐Ki Kim
出处
期刊:Journal of Controlled Release [Elsevier]
卷期号:350: 652-667 被引量:19
标识
DOI:10.1016/j.jconrel.2022.08.055
摘要

Carbon monoxide (CO) has been regarded as a "silent killer" for its toxicity toward biological systems. However, a low concentration of endogenously produced CO has shown a number of therapeutic benefits such as anti-inflammatory, anti-proliferative, anti-apoptosis, and cytoprotective activities. Carbon monoxide-releasing molecules (CORMs) have been developed as alternatives to direct CO inhalation, which requires a specialized setting for strict dose control. CORMs are efficient CO donors, with central transition metals (such as ruthenium, iron, cobalt, and manganese) surrounded by CO as a ligand. CORMs can stably store and subsequently release their CO payload in the presence of certain triggers including solvent, light, temperature, and ligand substitution. However, CORMs require appropriate delivery strategies to improve short CO release half-life and target specificity. Herein, we highlighted the therapeutic potential of inhalation and CORMs-delivered CO. The applications of conjugate and nanocarrier systems for controlling CO release and improving therapeutic efficacy of CORMs are also described in detail. The review concludes with some of the hurdles that limit clinical translation of CORMs. Keeping in mind the tremendous potential and growing interest in CORMs, this review would be helpful for designing controlled CO release systems for clinical applications.
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