肠易激综合征
腹泻
亚精胺
医学
免疫学
干扰素
内科学
生物
生物化学
酶
作者
Li Zhang,Haoli Wang,Shouxin Zhang,Xin-tao Mao,Tingting Wu,Zhihui Huang,Wan-jun Jiang,Ke-qi Fan,Dandan Liu,Bing Yang,Mei-Hui Zhuang,Guangming Huang,Yinming Liang,Shu Zhu,Jiang-yan Zhong,Guang-Yin Xu,Xiaoming Li,Qian Cao,Yi‐yuan Li,Jin Jin
标识
DOI:10.1016/j.cmet.2024.09.002
摘要
Irritable bowel syndrome with diarrhea (IBS-D) is a common and chronic gastrointestinal disorder that is characterized by abdominal discomfort and occasional diarrhea. The pathogenesis of IBS-D is thought to be related to a combination of factors, including psychological stress, abnormal muscle contractions, and inflammation and disorder of the gut microbiome. However, there is still a lack of comprehensive analysis of the logical regulatory correlation among these factors. In this study, we found that stress induced hyperproduction of xanthine and altered the abundance and metabolic characteristics of Lactobacillus murinus in the gut. Lactobacillus murinus-derived spermidine suppressed the basal expression of type I interferon (IFN)-α in plasmacytoid dendritic cells by inhibiting the K63-linked polyubiquitination of TRAF3. The reduction in IFN-α unrestricted the contractile function of colonic smooth muscle cells, resulting in an increase in bowel movement. Our findings provided a theoretical basis for the pathological mechanism of, and new drug targets for, stress-exposed IBS-D.
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