生物
造血
干细胞
计算生物学
祖细胞
谱系(遗传)
细胞命运测定
进化生物学
祖细胞
造血干细胞
基因组学
细胞生物学
遗传学
基因组
基因
转录因子
作者
Ksenia R. Safina,Peter van Galen
出处
期刊:Blood
[American Society of Hematology]
日期:2024-07-10
标识
DOI:10.1182/blood.2024024006
摘要
Recent advancements in single-cell genomics have enriched our understanding of hematopoiesis, providing intricate details about hematopoietic stem cell (HSC) biology, differentiation, and lineage commitment. Technological advancements have highlighted extensive heterogeneity of cell populations and continuity of differentiation routes. Nevertheless, intermediate 'attractor' states signify structure in stem and progenitor populations that link state transition dynamics to fate potential. We discuss how innovative model systems quantify lineage bias and how stress accelerates differentiation, thereby reducing fate plasticity compared to native hematopoiesis. We conclude by offering our perspective on the current model of hematopoiesis and discuss how a more precise understanding can translate to strategies that extend healthy hematopoiesis and prevent disease.
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