生物
免疫沉淀
赖氨酸
免疫印迹
胶溶蛋白
内科学
分子生物学
细胞生物学
生物化学
医学
氨基酸
基因
肌动蛋白
作者
Jie Ju,Kai Wang,Fang Liu,Cui-Yun Liu,Liang Wang,S. Wang,Lu‐Yu Zhou,Xinmin Li,Yuqin Wang,Xinzhe Chen,Rui Feng Li,Shijun Xu,Chen Chen,Meihua Zhang,Sumin Yang,Jinwei Tian,Kun Wang
标识
DOI:10.1161/circresaha.124.324733
摘要
Cardiac hypertrophy and its associated remodeling are among the leading causes of heart failure. Lysine crotonylation is a recently discovered posttranslational modification whose role in cardiac hypertrophy remains largely unknown. NAE1 (NEDD8 [neural precursor cell expressed developmentally downregulated protein 8]-activating enzyme E1 regulatory subunit) is mainly involved in the neddylation modification of protein targets. However, the function of crotonylated NAE1 has not been defined. This study aims to elucidate the effects and mechanisms of NAE1 crotonylation on cardiac hypertrophy.
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