Microbiome-metabolome reveals that the Suxiao Jiuxin pill attenuates acute myocardial infarction associated with fatty acid metabolism

代谢组 药丸 心肌梗塞 脂肪酸代谢 新陈代谢 生药学 医学 生物 传统医学 内科学 代谢物 药理学 生物活性 生物化学 体外
作者
Jingyu Liao,Yuhao Zhang,Chi Ma,Gaosong Wu,Weidong Zhang
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:312: 116529-116529 被引量:3
标识
DOI:10.1016/j.jep.2023.116529
摘要

The Suxiao Jiuxin pill (SJP) is a Chinese medical patent drug on the national essential drug list of China, with well-established cardiovascular protective effects in the clinic. However, the mechanisms underlying the protective effects of SJP on cardiovascular disease have not yet been elucidated clearly, especially its relationship with the gut microbiota.This study aimed to investigate the cardioprotective effect of SJP against isoproterenol-induced acute myocardial infarction (AMI) by integrating the gut microbiome and metabolome.A rat model of AMI was generated using isoproterenol. Firstly, the effect of antibiotic (ABX) treatment on the blood absorption and excretion of the main components of SJP were studied. Secondly, 16S rRNA sequencing and untargeted metabolomics were used to discover the improvement of SJP treatment on gut microbiota and host metabolism in AMI rats. Finally, targeted metabolomics was used to verify the effects of SJP treatment on host metabolism in AMI rats.The results showed that ABX treatment could affect the blood absorption and fecal excretion of the main active components of SJP. At the same time, SJP can restore the richness and diversity of gut microbiota, and multiple gut microbiota (including Jeotgalicoccus, Lachnospiraceae, and Blautia) are significantly associated with fatty acids. Untargeted metabolomics also found that SJP could restore the levels of various fatty acid metabolites in serum and cecal contents (p < 0.01, FC > 1.5 and VIP >1). Targeted metabolomics further confirmed that 41, 21, and 39 fatty acids were significantly altered in serum, cecal contents, and heart samples, respectively. Interestingly, these fatty acids belong to the class of eicosanoids, and SJP can significantly downregulate these eicosanoids in AMI rats.The results of this study suggest that SJP may exert its cardioprotective effects by remodeling the gut microbiota and host fatty acid metabolism.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zhengzhao应助爱撒娇的紫菜采纳,获得10
刚刚
卿莞尔完成签到 ,获得积分0
1秒前
书芹完成签到,获得积分10
1秒前
心灵美砖头完成签到,获得积分10
1秒前
szcyxzh完成签到,获得积分10
2秒前
领导范儿应助昂莫达采纳,获得10
2秒前
激昂的秀发完成签到,获得积分10
2秒前
豆腐kkkkk发布了新的文献求助10
3秒前
没头脑和不高兴完成签到,获得积分10
3秒前
3秒前
3秒前
顺利完成签到,获得积分10
5秒前
小蘑菇应助矮小的柠檬采纳,获得10
5秒前
Jahen完成签到,获得积分10
6秒前
今年一定离开癫胡完成签到,获得积分10
6秒前
7秒前
研友_VZG7GZ应助11采纳,获得10
7秒前
苹果萧完成签到 ,获得积分10
8秒前
Yxy2021发布了新的文献求助10
8秒前
衡阳完成签到,获得积分10
8秒前
乐闻发布了新的文献求助10
10秒前
alna完成签到,获得积分10
11秒前
微微发布了新的文献求助10
11秒前
阿江shk完成签到,获得积分10
11秒前
wddsf完成签到,获得积分10
11秒前
leadsyew完成签到,获得积分10
11秒前
长安完成签到,获得积分10
11秒前
hyekyo完成签到,获得积分10
12秒前
ren完成签到,获得积分10
12秒前
析渊完成签到,获得积分10
13秒前
11完成签到,获得积分10
14秒前
水濑心源发布了新的文献求助10
14秒前
Zero140发布了新的文献求助10
14秒前
W1ll完成签到,获得积分10
15秒前
15秒前
16秒前
16秒前
Owen应助俭朴从安采纳,获得10
16秒前
16秒前
完美世界应助fireking_sid采纳,获得10
16秒前
高分求助中
Nickel, Cobalt and Palladium Catalysed Infarction with Ventricular following rich structural diversity 1000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968608
求助须知:如何正确求助?哪些是违规求助? 3513486
关于积分的说明 11168243
捐赠科研通 3248926
什么是DOI,文献DOI怎么找? 1794540
邀请新用户注册赠送积分活动 875188
科研通“疑难数据库(出版商)”最低求助积分说明 804676