Robust strategies in nuclear-targeted cancer therapy based on functional nanomaterials

Recent advances of functional nanomaterials in cancer therapy are overviewed.Many nuclear targeting ligands are introduced to understand nuclear entry mechanism.The robust strategies are summarized to improve the nuclear delivery of nanocarriers.Current challenges in the clinical applications and future perspectives are discussed. g r a p h i c a l a b s t r a c tSchematic illustration of several nuclear-targeted drug delivery strategies, such as charge conversion, size ladder, dual targeting, light irradiation and stimulated responsive, for enhanced gene therapy, chemotherapy, phototherapy, combination therapy and CRISPE genome editing based therapy.