Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled study

医学 肝硬化 失代偿 生活质量(医疗保健) 随机对照试验 人口 医疗保健 门诊部 营养不良 急诊医学 内科学 物理疗法 护理部 经济增长 环境卫生 经济
作者
Maria Hjorth,Daniel Sjöberg,Anncarin Svanberg,Riccardo LoMartire,Elenor Kaminsky,Fredrik Rorsman
出处
期刊:BMJ Open Gastroenterology [BMJ]
卷期号:12 (1): e001694-e001694
标识
DOI:10.1136/bmjgast-2024-001694
摘要

Objectives Patients have difficulties in understanding how to manage their liver cirrhosis. This highlights a need for support in comprehending health-related information, which remains largely lacking within liver cirrhosis care. Involvement of registered nurses (RNs) in outpatient liver cirrhosis care has potential to improve quality of care and reduce patient mortality. However, the benefits of nursing care on patients’ health-related quality of life (HRQoL) are scarcely studied. This study compared HRQoL in patients receiving either standard medical outpatient care or adjunctive, nurse-led care. The risk of malnutrition, decompensation events and mortality were also compared between the two study groups. Methods This was a pragmatic, multicentre, randomised trial, which enrolled 167 patients with liver cirrhosis. The primary outcome measure, HRQoL, was assessed using the RAND-36 questionnaire. The physical component summary (PCS) and the mental component summary (MCS) scores of RAND-36 were compared, using linear mixed-effects models for repeated measures, at 12 and 24 months. Results 83 patients received standard medical care, and 84 patients received adjunctive, nurse-led care for 24 months. Due to unforeseen circumstances, the final study population of 167 participants was less than the intended 500. Group comparisons were non-significant of the PCS and MCS scores (−1.1, p=0.53 and −0.7, p=0.67, respectively), malnutrition (p=0.62) and decompensation events (p = 0.46), after 24 months. However, mortality was three times higher in the control group compared with the intervention group (12 vs 4, p=0.04) after 24 months. Conclusions In this study, adjunctive nurse-led care was not superior to standard medical outpatient care regarding HRQoL, risk of developing malnutrition or decompensation. However, RN involvement contributed to early identification of decompensation and reduced mortality. Trial registration number NCT02957253 .
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
大力的冬日完成签到,获得积分10
1秒前
HongY完成签到,获得积分10
1秒前
小酸奶完成签到,获得积分10
1秒前
脑洞疼应助梦XING采纳,获得10
1秒前
善学以致用应助sc采纳,获得10
1秒前
2秒前
2秒前
gogo完成签到,获得积分10
2秒前
李健应助Desheng采纳,获得10
2秒前
an完成签到,获得积分10
2秒前
water应助DJMZ采纳,获得10
2秒前
3秒前
3秒前
shanshui完成签到,获得积分10
3秒前
Flechozo完成签到,获得积分20
3秒前
5秒前
6秒前
顾矜应助鹿lu采纳,获得10
6秒前
6秒前
nuyoah完成签到,获得积分10
6秒前
煎饼发布了新的文献求助10
7秒前
YWD完成签到 ,获得积分10
7秒前
流流124141完成签到,获得积分10
8秒前
快乐茗发布了新的文献求助10
8秒前
9秒前
9秒前
Flechozo发布了新的文献求助10
9秒前
9秒前
小小宝完成签到,获得积分10
9秒前
幸运草发布了新的文献求助10
9秒前
李李完成签到,获得积分10
9秒前
10秒前
10秒前
10秒前
今天开始吃草完成签到,获得积分20
11秒前
11秒前
WangXiaoze发布了新的文献求助10
11秒前
满意黎昕完成签到,获得积分10
11秒前
LL发布了新的文献求助10
12秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974943
求助须知:如何正确求助?哪些是违规求助? 3519467
关于积分的说明 11198482
捐赠科研通 3255728
什么是DOI,文献DOI怎么找? 1797904
邀请新用户注册赠送积分活动 877261
科研通“疑难数据库(出版商)”最低求助积分说明 806224