Post-TIPS Right Atrial Pressure and Left Atrial Volume Index Predict Heart Failure and Mortality: Dual Center Experience

医学 左房压 心脏病学 内科学 中心静脉压 心力衰竭 对偶(语法数字) P波 血压 心房颤动 心率 艺术 文学类
作者
John Laurenzano,Previn Ganesan,Claire Harrington,James C. Slaughter,Lisa B. VanWagner,Anthony J. Borgmann,Deepak Gupta,Nikhilesh R. Mazumder,Justin Boike,Manhal Izzy
出处
期刊:The American Journal of Gastroenterology [American College of Gastroenterology]
标识
DOI:10.14309/ajg.0000000000003211
摘要

Background: Heart failure (HF) after Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement affects up to 20% of patients. Understanding factors associated with post-TIPS HF is critical. Cirrhotic Cardiomyopathy (CCM) is associated with adverse clinical outcomes. Aims: We aim to evaluate whether hemodynamic measurements and echocardiographic markers of CCM pre- and post-TIPS can predict post-TIPS HF and death. Methods: We performed a retrospective study of cirrhotic patients who underwent TIPS between 2010 and 2015 at two centers. Patients with cardiomyopathies other than CCM were excluded. A multivariable-adjusted time-to-event analysis assessed associations of clinical, hemodynamic, and echocardiographic parameters with post-TIPS HF and death during 2 years of follow-up. 180-day landmark analysis was used to assess association of echocardiographic changes with outcomes. Results: 360 patients met study criteria. 32 developed HF post-TIPS (8.8%). Right atrial pressure (RAP) measured intraprocedurally post-TIPS insertion was associated with increased risk for HF (adjusted HR 1.10 [1.04-1.17]), with a cut off of 22mm Hg associated with highest risk (multivariable HR 2.71, [1.22-6.02]. 92 patients died (25.5%). An increase in left atrial volume index (LAVI) within 180 days post-TIPS was associated with increased mortality (HR 1.08 [1.01-1.15]). Other echocardiographic CCM markers were not associated with HF or death. Conclusion: Increases in RAP and LAVI post-TIPS, but not CCM status, predict post-TIPS HF and death, respectively. Surveillance echocardiography may play a role in identifying those at highest risk of decompensation post-TIPS. Further prospective study of CCM and its markers in relation to TIPS outcomes is warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
fffff完成签到,获得积分10
刚刚
积极的凝海应助沉默听芹采纳,获得10
1秒前
领导范儿应助ttup采纳,获得10
1秒前
阿卡宁发布了新的文献求助10
2秒前
2秒前
3秒前
3秒前
xyf发布了新的文献求助30
4秒前
WYP发布了新的文献求助30
4秒前
CodeCraft应助阿九采纳,获得10
4秒前
Orange应助小高采纳,获得10
4秒前
wsqg123完成签到,获得积分10
5秒前
NexusExplorer应助NMR采纳,获得30
5秒前
5秒前
干净香寒发布了新的文献求助10
5秒前
丘比特应助晨时明月采纳,获得10
5秒前
斯文败类应助巧克力蛋仔采纳,获得10
6秒前
静丶发布了新的文献求助10
6秒前
season完成签到,获得积分20
7秒前
Denny完成签到,获得积分10
7秒前
甜甜若血完成签到,获得积分10
7秒前
小犁牛完成签到 ,获得积分10
8秒前
8秒前
8秒前
9秒前
FashionBoy应助小米采纳,获得10
9秒前
miqilin完成签到,获得积分10
11秒前
阳光青烟发布了新的文献求助10
11秒前
知性的剑身完成签到,获得积分10
11秒前
12秒前
12秒前
hxm发布了新的文献求助10
12秒前
12秒前
嗯哼举报CL求助涉嫌违规
13秒前
南风发布了新的文献求助10
13秒前
静丶完成签到,获得积分20
13秒前
13秒前
14秒前
阿卡宁完成签到,获得积分10
15秒前
普罗米休斯完成签到,获得积分10
15秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3256065
求助须知:如何正确求助?哪些是违规求助? 2898207
关于积分的说明 8300363
捐赠科研通 2567343
什么是DOI,文献DOI怎么找? 1394475
科研通“疑难数据库(出版商)”最低求助积分说明 652817
邀请新用户注册赠送积分活动 630501