Challenges of Legacy Chemicals

Legacy chemicals are unused chemicals, or even expired chemicals, that are no longer needed or usable for research but remain stored in laboratories, often for many years. This review examines the challenges posed by legacy chemicals in research institutions, categorizing them into four main types: old commercial chemicals, rebottled chemicals, research samples, and chemical-containing instruments. These chemicals create significant problems, including numerous safety hazards and financial costs. The origins of legacy chemical accumulation are introduced, such as overpurchasing and researchers leaving without proper cleanup. Strategies for addressing existing legacy chemical issues are presented. Approaches to prevent future accumulation include implementing robust institutional policies, maintaining accurate inventories, ensuring proper labeling, and establishing clear off-boarding procedures for researchers. The importance of a proactive, cradle-to-grave approach to chemical management in research settings is emphasized. By sharing experiences and approaches, the aim is to assist other institutions facing similar challenges with legacy chemicals and potentially apply these concepts to other research materials, such as biological samples.